Āshibio is a clinical-stage biotechnology company focused on developing treatments for bone and connective-tissue disorders, including FOP. Their lead programme, andecaliximab, is a humanised monoclonal antibody that targets MMP‑9, an enzyme linked to flare-ups and abnormal bone formation in FOP. Research suggests that reduced or altered MMP‑9 activity may help protect against heterotopic ossification, supported by both human genetic studies and animal models.
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